Interaction of aminoglycosides and other antibiotics with actin.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (2) , 156-160
- https://doi.org/10.7164/antibiotics.32.156
Abstract
Skeletal muscle actin was found by centrifugation, turbidity, and viscosity measurements to form polymers upon addition of aminoglycosides, viomycin, polymyxin B, and tetracycline. A linear relationship was observed between the amount of actin polymerization and the number of primary amino groups on the aminoglycoside antibiotics except kanamycin. Of the antibiotics studied, neomycin was most efficient in actin polymerization. Polymerization of actin was not significantly induced by kasugamycin, chloramphenicol, erythromycin, benzylpenicillin, angustmycin A, formycin, actinomycin D, and mitomycin C. Aminoglycosides and viomycin were demonstrated to inhibit the acto-HMM Mg2+-ATPase reaction but did not significantly affect HMM Mg2+-ATPase activity. It was found by equilibrium dialysis that [3H]dihydrostreptomycin bound to actin.This publication has 7 references indexed in Scilit:
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