LAMELLAR ATROPHY OF THE PURKINJE CELLS FOLLOWING HEAT STROKE
- 1 April 1949
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 61 (4) , 441-444
- https://doi.org/10.1001/archneurpsyc.1949.02310100105009
Abstract
SURVIVORS of an attack of heat stroke present occasionally a severe cerebellar syndrome; the clinical signs—ataxia, dysarthria and hypotony—are well known; not so the pathologic changes. Freeman and Dumoff1 examined sections of the cerebellum of a patient who died twenty-four hours after onset of a severe heat stroke without regaining consciousness. They noted extensive involvement of the Purkinje cells, "many being absent and the rest in a state of coagulation necrosis" and stated the belief that the destruction of Purkinje cells "is the most permanent and significant pathologic change in cases of cerebellar syndrome following hyperpyrexia." The case to be described here appears to be the second one recorded in which this type of cerebellar change has been recognized; in this case, unlike that reported by Freeman and Dumoff, the atrophy of the Purkinje cells was practically complete. REPORT OF A CASE Fusilier A. S., a European aged 33,Keywords
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