Prolonged Adverse Effects of Haloperidol in Normal Subjects

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Abstract
To the Editor: Haloperidol is being used increasingly for the treatment of various psychiatric conditions, producing well-known side effects. However, its effects in normal persons have not been studied systematically. We report adverse effects of unexpected duration and severity in normal volunteers.Three men 28 to 32 years old volunteered to participate in a double-blind experiment to determine the effect of oral haloperidol (5 mg) on plasma levels of beta-endorphin. Levels of haloperidol were assayed as well. All three subjects had pronounced akathisia (a desire to keep moving), which lasted from 36 hours to five days. They also had dysphoria. . . .

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