ENZYME-INDUCTION BY ORTHO-XYLENE INHALATION
- 1 January 1980
- journal article
- research article
- Vol. 37 (1) , 115-120
Abstract
Inhalation of 4500 mg o-xylene [an industrial solvent] by rats produced adaptational and pathologic changes in the liver by the end of wk 1 reflected in increased relative liver weight, shortening of hexobarbital sleeping time, increased concentration of cytochrome P-450, with decreased activities of aniline hydroxylase and aminopyrine N-demethylase. Six wk after start of inhalations all changes in liver and mixed function oxydase system (MFO) were of an adaptational pattern characterized by increased relative liver weight and cytochrome P-450 and b5 concentrations, shortening of hexobarbital sleeping time and increased activity of aniline hydroxylase and aminopyrine N-demethylase.This publication has 6 references indexed in Scilit:
- Long-term studies on chemically induced liver enlargement in the rat I. Transient induction of microsomal enzymes leading to liver damage and nodular hyperplasia produced by safrole and ponceau MXToxicology, 1977
- Long-term studies on chemically induced liver enlargement in the rat I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytolueneToxicology, 1977
- Evidence for Biochemically Different Types of Vesicles in the Hepatic Microsomal Fraction*The Journal of Biochemistry, 1966
- PHENOBARBITAL-INDUCED FINE STRUCTURAL CHANGES IN RAT LIVER1966
- Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing EnzymesScience, 1963
- The colorimetric estimation of formaldehyde by means of the Hantzsch reactionBiochemical Journal, 1953