Analysis of sodium current fluctuations in the cut-open squid giant axon.
Open Access
- 1 February 1984
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 83 (2) , 133-142
- https://doi.org/10.1085/jgp.83.2.133
Abstract
Patch pipettes were used to record the current arising from small populations of Na channels in voltage-clamped cut-open squid [Loligo pealei and L. opalescens] axons. The current fluctuations associated with the time-variant Na conductance were analyzed with nonstationary statistical techniques in order to obtain an estimate for the conductance of a single Na channel. The results presented support the notion that the open Na channel in the squid axon has only one value of conductance, 3.5 pS.Keywords
This publication has 11 references indexed in Scilit:
- Modification of single Na+ channels by batrachotoxin.Proceedings of the National Academy of Sciences, 1982
- Fluctuation of No and K Currents in Excitable MembranesPublished by Elsevier ,1982
- Currents recorded through small areas of squid axon membrane with an internal virtual ground voltage clampBiophysical Journal, 1981
- Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesPflügers Archiv - European Journal of Physiology, 1981
- Unitary current through sodium channel and anomalous rectifier channel estimated from transient current noise in the tunicate egg.The Journal of Physiology, 1981
- Current recorded from a cut-open giant axon under voltage clamp.Proceedings of the National Academy of Sciences, 1980
- The variance of sodium current fluctuations at the node of RanvierThe Journal of Physiology, 1980
- Single Na+ channel currents observed in cultured rat muscle cellsNature, 1980
- Sodium channels in nerve apparently have two conductance statesNature, 1977
- Potassium and sodium ion current noise in the membrane of the squid giant axon.The Journal of Physiology, 1975