Responses of Specific-Pathogen-Free Chicks to Concomitant Infections of Reovirus (WVU-2937) and Infectious Bursal Disease Virus

Abstract
Specific pathogen-free white leghorn chicks concomitantly infected with infectious bursal disease virus (IBDV) and reovirus (WVU-2937) on day 1 had significantly lower (P < 0.05) virus neutralizing and precipitating antibody geometric mean titers (GMT) to reovirus than chicks infected with only reovirus on day 1, but had a similar incidence of inflammation of the metatarsal digital flexor tendons. Chicks infected with IBDV on day 7 and reovirus on day 14 had a greater incidence of inflammation of the tarsometatarsal digital flexor tendons and lower neutralizing and precipitating antibody GMT to reovirus than chicks infected with only reovirus on day 14. Chicks infected with both viruses on day 1 had a significantly lower (P < 0.05) neutralizing antibody GMT to IBDV than chicks infected with only IBDV.