Phalloidin depletes the mitochondrial Ca2+compartment of hepatocytes
Open Access
- 27 February 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 167 (2) , 241-244
- https://doi.org/10.1016/0014-5793(84)80134-9
Abstract
In 3 h of incubation, primary cultures of rat hepatocytes attach to the substratum and exchange about 2.2 nmol 45Ca2+ per mg protein. In the presence of 1 μM phalloidin, the exchanged amount of 45Ca2+ was found to be decreased by about 30%. Using the uncoupling agent FCCP and the ionophore A23187 for further characterisation we determined that the 45Ca2+ deficit caused by phalloidin occurs in the FCCP‐sensitive compartment, i.e., the mitochondria.Keywords
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