Taurine selectively antagonizes l-kynurenine-produced seizures in mice
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 48 (4) , 311-316
- https://doi.org/10.1007/bf01250666
Abstract
Taurine in doses of 100 and 200 mg/kg (intraperitoneally) and 2.5μg (into brain ventricles) antagonized clonic seizures produced by L-kynurenine sulfate injected into brain ventricles of SHR adult male albino mice. Seizures produced by another metabolite of tryptophan in the kynurenine pathway, quinolinic acid, were intensified. The convulsant effects of strychnine, pentylenetetrazol and thiosemicarbazide was not modified.This publication has 8 references indexed in Scilit:
- Effect of tryptophan metabolites on activity of the epileptogenic focus in the frog hippocampusJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1980
- [Effect of taurine on audiogenic convulsive seizures in rats].1979
- Effects of Taurine, Glycine and GABA on Convulsions Produced by Strychnine in the RabbitEuropean Neurology, 1979
- Stimulant and convulsive effects of kynurenines injected into brain ventricles in miceJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1978
- Convulsions and tremor in immature rats after intraperitoneal injection of kynurenine and its metabolitesPharmacological Research Communications, 1978
- [Therapeutic effects of taurine in epilepsy: a clinical and polyphysiographic study (author's transl)].1975
- First Clinical Experience on the Antiepileptic Action of TaurineEuropean Neurology, 1974
- TAURINE IN EPILEPSYThe Lancet, 1973