Another view of GH neuroregulation: lessons from the sheep

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Abstract
Introduction Growth hormone (GH) secretion is controlled mainly by two hypothalamic peptides, GH-releasing hormone (GHRH) and somatostatin (SRIH), which act by respectively stimulating and inhibiting GH secretion (1). In mammalians, the secretion of GH is pulsatile and influenced by various conditions including stress, feeding and pharmacological manipulations that involve central neurotransmitters (2). It is generally believed that both the pattern of pulsatile GH secretion and the responses to physiological or pharmacological stimuli depend upon the exquisite interrelationship between GHRH and SRIH secretion and action in the pituitary (3). Some information has been obtained from clinical studies, but animal experiments are needed on GH neuroregulation, for which human studies are ethically or practically impossible. Most studies on the neuroregulation of GH secretion have been performed in the male rat and have concluded that reciprocal changes of GHRH and SRIH release into hypophysial portal blood (HPB) generate GH pulses and troughs (4).

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