Synthesis and Pharmacological Properties of 2-[S-Acetylthiorphan]-l,3-diacylaminopropan-2-ol Derivatives as Chimeric Lipid Drug Carriers Containing an Enkephalinase Inhibitor
- 1 January 1995
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 12 (2) , 187-191
- https://doi.org/10.1023/a:1016214506667
Abstract
The design of 1,3-diacylaminopropan-2-ols as CNS-directed carrier groups is based on their resemblance to endogenous lipids and the properties of pseudotriglyceride esters to facilitate the brain...Keywords
This publication has 18 references indexed in Scilit:
- 1,3-Diacylaminopropan-2-ols and Corresponding 2-Acyl Derivatives as Drug Carriers: Unexpected Pharmacological PropertiesJournal of Pharmacy and Pharmacology, 1993
- Drug transport across the blood-brain barrierInternational Journal of Clinical Pharmacy, 1992
- Antiepileptic activity of 1,3-dihexadecanoylamino-2-valproyl-propan-2-ol, a prodrug of valproic acid endowed with a tropism for the central nervous systemJournal of Pharmacy and Pharmacology, 1991
- Synthesis, brain uptake, and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor .gamma.-vinyl-GABAJournal of Medicinal Chemistry, 1990
- .gamma.-Aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 glyceryl lipid esters of GABA with varying degree of unsaturationJournal of Medicinal Chemistry, 1987
- .gamma.-Aminobutyric acid esters. 2. Synthesis, brain uptake, and pharmacological properties of lipid esters of .gamma.-aminobutyric acidJournal of Medicinal Chemistry, 1985
- Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme. Molecular investigation by use of new thiol inhibitorsEuropean Journal of Biochemistry, 1984
- 1,3-Dipalmitoylglycerol ester of chlorambucil as a lymphotropic, orally administrable antineoplastic agentJournal of Medicinal Chemistry, 1983
- Thiorphan potentiation of stress-induced analgesia in the mouseLife Sciences, 1982
- Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful StimuliScience, 1977