Allergic hypersensitivity to neomycin. Relationship between patch test reactions and 'use' tests

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Abstract
The prevalence of neomycin patch test sensitivity in the general population is approximately 1%. The relationship between positive neomycin patch tests and clinical use tests with 2 antibiotic combinations (Neosporin G cream and Neosporin ointment) was described. The neomycin use test was positive in 7 of 8 subjects with a stongly positive patch test, and in 2 of 4 subjects with a weakly positive patch test. A positive use test usually occurred earlier and was always more intense with the cream base. The use test reactions were usually mild, even with continued application of the antigen. Use tests with commerical products may be helpful in evaluating the clinical relevance of positive patch tests.

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