Antiarrhythmic and Cardiovascular Effects of Synthetic Oxytocin

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Abstract
Cardiac arrhythmias were produced in the cat by the inhalation of : halopropane, halopropane and 10% CO2, cyclopropane and 10% CO2. The injection of 20 U/kg of Syntocinon temporarily restored a normal sinus rhythm. This dose of Syntocinon also prevented arrhythmias produced by the injection of norepinephrine during the inhalation of halopropane or cyclopropane. The antiarrhythmic dose of Syntocinon (10 or 20 U) was also demonstrated in 13 of 20 patients who developed cardiac arrhythmias during anesthesia and operation. Syntocinon, in man, produced a transient (30-60 seconds) fall in blood pressure (20-40 mm. of mercury) and a secondary rise of 5-15 mm. of Hg which lasted 2-5 minutes. A 1-2 minute increase in heart rate of 10-20 beats/minute was frequently seen.

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