Myocardial digoxin uptake in pressure overload right ventricular hypertrophy

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Abstract
The hypertrophied right ventricle of the dog with pulmonary stenosis exhibited a greater than normal uptake of digoxin 5 min after intravenous administration. After 1 hr the digoxin concentration had fallen and was not different from the normal, this latter result suggesting that hypertrophy per se did not change the ventricle's binding affinity for digoxin per unit mass. Greater initial binding of digoxin by the hypertrophied ventricle was probably associated with some function of the mechanical activity of the stressed ventricle and/or with greater tissue delivery of digoxin in greater myocardial blood flow.

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