ACTION OF SURUGATOXIN ON NICOTINIC RECEPTORS IN THE SUPERIOR CERVICAL GANGLION OF THE RAT
Open Access
- 1 September 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 58 (1) , 157-159
- https://doi.org/10.1111/j.1476-5381.1976.tb07705.x
Abstract
Surugatoxin (SGTX, 0.1–2 μm) reversibly depressed orthodromic transmission and antagonized the depolarizing action of carbachol on the isolated superior cervical ganglion of the rat. The apparent dissociation equilibrium constant against carbachol-induced depolarization (measured in the presence of hyoscine) was 58 and 76 nm determined at 0.2 and 2 μm respectively. SGTX (2 μm) did not reduce the depolarizing effects of (±)-muscarine, γ-aminobutyric acid or angiotensin, but did reduce that to 5-hydroxytryptamine. Release of [3H]-acetylcholine following repetitive (10 Hz) preganglionic sympathetic stimulation was maintained in the presence of 2 μm SGTX. It is concluded that SGTX has a high and selective affinity for ganglionic nicotinic receptors.Keywords
This publication has 5 references indexed in Scilit:
- PHARMACOLOGICAL STUDIES ON SURUGATOXIN, THE TOXIC PRINCIPLE FROM JAPANESE IVORY MOLLUSC (Babylonia japonica)British Journal of Pharmacology, 1975
- Isolation and structure determination of a new marine toxin, surugatoxin from the Japanese ivory shell, babylonia japonicaTetrahedron Letters, 1972
- The binding of labelled tetrodotoxin to non‐myelinated nerve fibresThe Journal of Physiology, 1972
- Origin of the after‐hyperpolarization that follows removal of depolarizing agents from the isolated superior cervical ganglion of the ratBritish Journal of Pharmacology, 1972
- Evidence against a Presynaptic Action of Acetylcholine during Ganglionic TransmissionNature, 1970