QUANTITATIVE ACID-BASE RELATIONSHIPS IN CHRONIC PULMONARY PATIENTS DURING STABLE STATE

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Abstract
The quantitative response of plasma bicarbonate and H ion concentration of different PcO2 [CO2 pressure] levels were studied in 247 arterial blood samples obtained from 106 patients with chronic pulmonary disease who were in the clinically stable state. The results of this in vivo titration curve indicates the presence of regulatory mechanism to altered PCO2 that is remarkably effective in preventing extracellular acidosis up to about 65 mm of PcO2 Statistical analysis allowed the construction of a significant band of expected pH and bicarbonate values considered to be the physiologic response to various degrees of PCO2 in these patients. Values falling outside these limits should be suspected of indicating primary associated metabolic complications.