INDIUM 113m DIETHYLTRIAMINOPENTACETIC ACID (DTPA): A NEW RADIOPHARMACEUTICAL FOR BRAIN SCANNING

1 September 1968

journal article
Published by American Roentgen Ray Society in American Journal of Roentgenology

Vol. 104 (1) , 139-144
https://doi.org/10.2214/ajr.104.1.139

Abstract

We have developed and evaluated a new [See figure in the PDF file] radiopharmaceutical, indium 113m diethyltriaminopentacetic acid (DTPA) as a brain scanning agent. In¹¹³ which has a half-life of 1.7 hours is obtained in ionic, carrierfree form by elution of a Sn¹¹³ (tin) generator system. The chelate In^113m DTPA can be perpared simply and rapidly. Satisfactory [See table in the PDF file] tumor: brain concentration ratios were found in experimental tumors in mice and in brain tumors in man. Over 400 brain scannings have been performed with satisfactory results and without untoward effects. In 87 patients, brain scannings with both Tc^99m pertechnetate and In^113m DTPA were carried out. The images were essentially the same with both agents. In^113m DTPA was found to be comparable to Tc^99m pertechnetate in the detection and characterization of intracranial lesions. The long half-life of 118 days of the parent Sn¹¹³ is an advantage since replenishment is required only at 6 month intervals rather than weekly as in the case of the Mo⁹⁹/Tc^99m generator.

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