Synthesis of cystine-peptide by a new disulphide bond-forming reaction using the siiyl chloride–sulphoxide system
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 167-168
- https://doi.org/10.1039/c39910000167
Abstract
Methyltrichlorosilane or tetrachlorosilane in trifluoroacetic acid, in the presence of diphenylsulphoxide, is found to cleave various S-protecting groups of cysteine to form cystine directly by the reduction–oxidation reaction; this new disulphide bond forming reaction is successfully applied to the syntheses of oxytocin and human brain natriuretic peptide.Keywords
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