Asymmetric Synthesis of the Quinolizidine Alkaloid (−)-Epimyrtine with Intramolecular Mannich Cyclization and N-Sulfinyl δ-Amino β-Ketoesters

Abstract
A concise, six-step, enantioselective synthesis of (−)-epimyrtine employing the N-sulfinyl δ-amino β-ketoester chiral building block is described.