Eph-modulated Cell Morphology, Adhesion and Motility in Carcinogenesis
Open Access
- 1 June 2005
- journal article
- review article
- Published by Wiley in IUBMB Life
- Vol. 57 (6) , 421-431
- https://doi.org/10.1080/15216540500138337
Abstract
Eph receptor tyrosine kinases (Ephs) and their membrane anchored ephrin ligands (ephrins) form an essential cell‐cell communication system that directs the positioning, adhesion and migration of cells and cell layers during development. While less prominent in normal adult tissues, there is evidence that up‐regulated expression and de‐regulated function of Ephs and ephrins in a large variety of human cancers may promote a more aggressive and metastatic tumour phenotype. However, in contrast to other RTKs, Ephs do not act as classical proto‐oncogenes and do not effect cell proliferation or differentiation. Mounting evidence suggests that Eph receptors, through de‐regulated re‐emergence of their mode of action in the embryo may direct cell movements and positioning during metastasis, invasion and tumour angiogenesis. This review discusses these and other emerging roles of Eph receptors during oncogenesis. IUBMB Life, 57: 421‐431, 2005Keywords
This publication has 81 references indexed in Scilit:
- EphrinB1 Is Essential in T-cell-T-cell Co-operation during T-cell ActivationJournal of Biological Chemistry, 2004
- A relative signalling model for the formation of a topographic neural mapNature, 2004
- Diverse Roles of Eph Receptors and Ephrins in the Regulation of Cell Migration and Tissue AssemblyDevelopmental Cell, 2004
- Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signalingNature Neuroscience, 2004
- Ephrin-A1 Induces c-Cbl Phosphorylation and EphA Receptor Down-Regulation in T CellsThe Journal of Immunology, 2003
- Molecular control of arterial-venous blood vessel identityJournal of Anatomy, 2003
- Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesisMicroscopy Research and Technique, 2002
- Mechanisms and functions of eph and ephrin signallingNature Reviews Molecular Cell Biology, 2002
- Eph family functions from an evolutionary perspectiveCurrent Opinion in Genetics & Development, 2002
- Eph receptors and neural plasticityNature Reviews Neuroscience, 2001