Nodules of the legs are often difficult diagnostic problems. The clinical patterns may be similar in erythematous nodules of widely varying causation, and biopsy of the lesions may reveal a nonspecific pattern of acute or chronic inflammation involving dermis, vessels, or fat. In the consideration of chronic inflammatory lesions one should keep several conditions in mind. These include erythema induratum, nodular vasculitis, and erythema nodosum; conditions in which the vessels are primarily involved, such as periarteritis nodosa and migratory thrombophlebitis; and finally those in which the panniculus is primarily involved, namely febrile relapsing nodular nonsuppurative panniculitis (Weber-Christian disease) and lipogranulomatosis subcutanea of Rothmann and Makai. In 1956, Vilanova and Aguadé1described subacute nodular migratory panniculitis and emphasized its features that led them to believe that it is a distinct and independent entity. Additional reports by these authors and others confirm the impression that this is a specific clinical syndrome.