Ki-1+ Cutaneous Lymphoma
- 1 March 1988
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 124 (3) , 405-408
- https://doi.org/10.1001/archderm.1988.01670030071025
Abstract
• Cutaneous malignant lymphomas developed in an 80-year-old man without any evidence of leukemic disseminations of lymphoma cells. Immunohistologic staining showed the expression of Leu-3a, Leu-4, Ki-1, Tac, and HLA-DR antigens on tumor cells in tissue and large lymphoid cells in long-term, interleukin 2-containing culture of tumor explants. DNA samples extracted from the skin tumors and cultured lymphoid cells showed a clonal rearrangement of T-cell receptor (TCR) gene Cβ1 with the molecular size of 9 kilobases. These findings suggested the T-cell origin of Ki-1+ cutaneous lymphoma cells and the occurrence of a clonal proliferation of tumor cells in culture. (Arch Dermatol 1988;124:405-408)Keywords
This publication has 3 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes.The Journal of Experimental Medicine, 1985
- DELETION OF IMMUNOGLOBULIN HEAVY CHAIN GENES ACCOMPANIES THE CLASS SWITCH REARRANGEMENT Biomedical Research, 1980