Variation in the appearance of giant condyloma in an Ugandan series of cases of carcinoma of the penis

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Abstract
Whole mount sections were made from all amputation specimens of patients treated for carcinoma of the penis in Mulago Hospital, Kampala, Uganda, during a 21-mo. period in 1968-1970. Among 55 cases 4 tumors were found which were large, but histologically showed low invasiveness suggestive of absence of metastatic spread. These were 2 giant condylomas, and 2 giant condylomas showing possible microinvasion. Two further cases showed a small squamous cell carcinoma together with a giant condyloma in the remainder of the tumor. The most characteristic feature was an orderly, well-circumscribed, expansive downgrowth, leaving little stroma to be seen between the epithelial masses of tumor. Within these limits, the spectrum of growth pattern, differentiation and malignant change was very wide and more varied than in tumors recorded from Western countries. This should be remembered when a presumptive diagnosis of the condition is to be made on small routine biopsies. Additional changes showing marked similarities to condylomata acuminata were often seen in superficial portions of the tumor. This transition in histological picture within 1 tumor favors the view that giant condyloma is an intermediate lesion in the development of cancer in condylomata acuminata.