Desmosine Biosynthesis: Nature of Inhibition by D-Penicillamine
- 2 August 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 161 (3840) , 475-476
- https://doi.org/10.1126/science.161.3840.475
Abstract
Administration of D-penicillamine and lathyrogens such as β-amino-propionitrile to animals markedly alters connective tissue by preventing the normal cross-linkage of elastin and collagen. It had been shown that β-aminopropionitrile blocks the cross-linkage of elastin and collagen by preventing the initial step in cross-linkage: the conversion of lysine in peptide linkage to α-amino adipic-δ-semialdehyde. We show that penicillamine acts after the initial step, causing the accumulation of an elastin rich in α-amino adipic-δ-semialdehyde.Keywords
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