Complete Nucleotide Sequence of the Mouse Lactate Dehydrogenase-A Functional Gene: Comparison of the Exon-Intron Organization of Dehydrogenase Genes
Open Access
- 1 May 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 116 (1) , 99-105
- https://doi.org/10.1093/genetics/116.1.99
Abstract
The complete sequence of 12,851 nucleotides of the mouse lactate dehydrogenase-A (LDH-A) gene has been determined. It includes eight exons, seven introns, promoter and regulatory regions. The B1 repetitive elements present in intron III and VI are oriented in opposite orientation, and they share 72% sequence homology. The exon-intron organization of mouse LDH-Agene is compared with the organizations of other dehydrogenase genes, and the molecular evolution of the nicotinamide adenine dinucleotide binding domains is discussed.This publication has 31 references indexed in Scilit:
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