Spider sedation induced by defensive chemicals of milliped prey

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Abstract
Wolf spiders (Lycosa spp.) show delayed induced sedation (total immobilization) of prolonged duration (in the order of days) after attacks upon millipeds (G. marginata). The sedation is specifically attributable to glomerine and homoglomerin, 2 previously characterized quinazolinones present in the defensive secretion of Glomeris. Median sedative doses for the quinazolinones are in the range of 1-7 .mu.g per spider, a fraction of the total (60-90 .mu.g) present in the secretion of medium to full-grown millipeds. A sedative effect upon an invertebrate predator has not previously been demonstrated for an animal defense. Quinazolinones include the synthetic drug methaqualone (Quaalude), a potent human sedative.