On Keeping One's Eye on the Ball: Analysis of Biologic Specimens for Copper

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Abstract
In 1887 the state of the art and the science was such that Osler wrote that there were two groups of pneumonia patients "... the alcoholic and the temperate; the majority of the former die in spite of all treatment; the majority of the latter get well with any, or with no, treatment."1 It frequently made little difference to the patient if the diagnosis of his illness was correct, in obvious contrast to the patient today with pneumonia or with one of many other illnesses. Consider, as one of the latter, Wilson's disease.Wilson, over 50 years ago, defined the . . .