Threonine Catabolism in Trypanosoma brucei

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Abstract
L-Threonine is catabolized by T. brucei to give equimolar quantities of glycine and acetate. The pathway, which involves the 2 enzymes L-threonine dehydrogenase (EC 1.1.1. 103) and aminoacetone synthase (acetyl-CoA: glycine C-acetyltransferase, EC 2.3.1.29) and subsequent hydrolysis of the acetyl-CoA, is most active in cultured trypanosomes, but is present in bloodstream forms. L-Threonine dehydrogenase from both culture and bloodstream forms of trypanosomes has an apparent MW between 28,000-38,000 and is sensitive to a wide range of sulfhydryl reagents.

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