Evolution of Seizure Patterns in Experimental Epilepsy

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Abstract
Epileptogenic lesions in deep brain structures of 37 cats were produced by injections of small amounts of metallic Co combined with alumina cream. Epileptic states developed in 40% of the animals and varied within a wide range between focal and generalized seizure patterns. A close correlation between eeg findings and anatomical localization could not be established. In several instances isolated thalamic lesions failed to be effective. In one case with several episodes of seizures reminding one of petit-mal-status, the lesion involved the intralaminar thalamus and the homolateral cortex of the midline. The dynamic course of evolution of experimental seizure patterns was emphasized since the type of epilepsy changed in many animals from day to day. In close correspondence with this observation is the fact that site and extent of the primary focus [long dash] which in itself seems to release both irritative and destructive mechanisms[long dash]is complicated by the development of secondary structural changes. These can be attributed to the seizures and to secondary degeneration as well.

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