Castes, Migration, Immunogenetics and Infectious Diseases in South India
- 1 November 2002
- journal article
- Published by S. Karger AG in Public Health Genomics
- Vol. 5 (3) , 157-161
- https://doi.org/10.1159/000066329
Abstract
It has been said that the grandest genetic experiment of nature has been conducted in south India in the name of the caste system. One can expect the frequency of an infectious disease to be equal to the product of the frequencies of various indicated loci/alleles, whether physiological, hormonal or immunological, in an endemic area. The sympatrically isolated caste and sub-caste populations of southern India, with differing origins, migration patterns and breeding habits, differ significantly in their HLA and other immune repertoire and are ideal models to study and test this hypothesis. The prevalence of a number of major infectious diseases, including TB and leprosy, are reviewed in different communities in the light of their genetic history.Keywords
This publication has 6 references indexed in Scilit:
- Association of Interleukin-10 Cytokine Expression Status with HLA Non-DRB1*02 andMycobacterium bovisBCG Scar-Negative Status in South Indian Pulmonary Tuberculosis PatientsInfection and Immunity, 2001
- The Eurasian Heartland: A continental perspective on Y-chromosome diversityProceedings of the National Academy of Sciences, 2001
- A major susceptibility locus for leprosy in India maps to chromosome 10p13Nature Genetics, 2001
- Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south IndiaTubercle and Lung Disease, 1999
- Behçet’s disease, the Silk Road and HLA‐B51: historical and geographical perspectivesTissue Antigens, 1999
- THE IMMUNOGENETICS OF HUMAN INFECTIOUS DISEASESAnnual Review of Immunology, 1998