The Influence of Intraduodenal Administration of Pancreatic Juice on the Bile-Induced Pancreatic Secretion and Immunoreactive Secretin Release in Man

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Abstract
The exocrine pancreatic secretion of water, bicarbonate, amylase and protein and the plasma levels of immunoreactive secretin (IRS) were studied after intraduodenal infusions of bile and pancreatic juice. Pancreatic secretion was obtained by endoscopic cannulation of the main pancreatic duct. Bile and pancreatic juice were infused into the duodenum through separate catheters attached to the outside of the duodenoscope. The unstimulated secretion was collected for 20 min. After intraduodenal stimulation of the pancreatic secretion with a nearly neutral solution of dried cattle bile, juice was collected for another 20 min period. Then, pure pancreatic juice was infused into the duodenum. Pancreatic juice evidently reduced the flow rate and output of bicarbonate, amylase and protein significantly (P < 0.05). A significant reduction in plasma concentration of IRS (P < 0.05) was also found. In the controls, i.e., when no pancreatic juice was instilled into the duodenum, a further increase in flow rate, bicarbonate secretion and IRS was found. The exocrine pancreatic secretion and IRS release induced by intraduodenal administration of bile may be depressed by reinfusions of pancreatic juice. Secretin may play an important role in the exocrine pancreatic secretion induced by intraduodenal infusion of bile.