EFFECTS OF SULPHASALAZINE ON FAECAL FLORA IN PATIENTS WITH RHEUMATOID ARTHRITIS: A COMPARISON WITH PENICILLAMINE
- 1 October 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 26 (5) , 334-337
- https://doi.org/10.1093/rheumatology/26.5.334
Abstract
Twenty-six out-patients with active rheumatoid arthritis (RA) were randomly allocated to treatment with sulphasalazine (SASP) or D-penicillamine (DPA). Faecal samples were collected from all patients at 4-weekly intervals and examined for changes in faecal flora during treatment. Both treatment groups showed substantial clinical improvement. In the SASP-treated group this was accompanied by significant falls in counts of Cl. perfringens and E. coli. No such changes were seen in the DPA-treated group. These results suggest that SASP's efficacy in RA may be related to its antibacterial properties.Keywords
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