Two types of lambda polypeptide chains in human immunoglobulins based on an amino acid substitution at position 190.
- 1 May 1967
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 57 (5) , 1449-1454
- https://doi.org/10.1073/pnas.57.5.1449
Abstract
Two forms of lambda Bence-Jones proteins, differing in a single amino acid in the invariant region, have been demonstrated. These polypeptide chains occur in 2 antigenic types, Oz (+) and Oz (-). Of 12 proteins studied, the seven Oz (+) proteins have lysine at position 190 and 5 Oz (-) proteins have arginine at the same position. This amino acid interchange resembles the interchange at position 191 of kappa polypeptide chains which is associated with the allotypic Inv factors.This publication has 16 references indexed in Scilit:
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