Adenosinetriphosphate in rat renal papilla: effects of vasopressin and of ischemia

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Abstract
This study examined the influence of exogenous and endogenous vasopressin on the content of adenosinetriphosphate (ATP) in the cortex and in the papilla of rat kidneys. The data demonstrate that the ATP content of the papilla is diminished in hydrated rats given vasopressin and in dehydrated rats when compared with water-loaded rats to whom no vasopressin was administered. The possible signifi-cance of this interrelationship between vasopressin and the steady-state level of ATP in the papilla is discussed in terms of the metabolic responses to vasopressin in relationship to the urine concentrating mechanism.