Effect of Chemical Deglycosylation on the in vivo Fate of Ricin A-Chain
- 1 January 1986
- journal article
- research article
- Published by Mary Ann Liebert Inc in Cancer Drug Delivery
- Vol. 3 (3) , 189-196
- https://doi.org/10.1089/cdd.1986.3.189
Abstract
Chemical deglycosylation of ricin A-chain virtually eliminated its entrapment by the liver and delayed its clearance from the bloodstream of mice. Liver entrapment of native ricin A-chain occured to approximately equal extents in the parenchymal and non-parenchymal cell fractions of the liver. The chemical deglycosylation procedure reduced uptake of the A-chain by both cell fractions.Keywords
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