Synthesis and aldose reductase-inhibitory activities of structural analogues of WF-3681, a novel aldose reductase inhibitor.

Publisher Website
Google Scholar
Abstract
Various analogues of WF-3681 (1a), a novel aldose reductase inhibitor, were synthesized and examined for aldose reductase-inhibitory activity. It was found that the carboxylic acid function is necessary and the side-chain length is important for the activity. Furthermore, the lipophilicites of the benzene ring and the enol ether group are significant for increasing the activity.

This publication has 0 references indexed in Scilit: