A Virus Encountered in the Study of Material from Cases of Encephalitis in the St. Louis and Kansas City Epidemics of 1933

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Abstract
A disease resembling encephalitis was transmitted to mice by intracerebral injection of brain tissue from fatal cases in St. Louis. The disease was transmitted regularly after the first passage and could be maintained indefinitely. The active agent, passed through Berke-feld-N filters, was highly virulent when instilled in the nasal passages of mice, was not neutralized by sera of normal non-contacts, but was neutralized by sera of convalescents from the St. Louis and Kansas City epidemics. A similar virus was obtained from a fatal case in Kansas City. Mouse-brain virus injected intracerebrally into Macacus rhesus monkeys induced a disease resembling the human one. The virus did not appear to be related to louping-ill, vesicular stomatitis, equine encephalomyelitis, or herpes.

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