A COMPARATIVE STUDY OF SODIUM, CHLORIDE AND BLOOD PRESSURE CHANGES INDUCED BY ADRENAL INSUFFICIENCY, TRAUMA AND INTRAPERITONEAL ADMINISTRATION OF GLUCOSE

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Abstract
Observations were made on 35 dogs. Mild muscle trauma or intraperit. injections of isotonic glucose (50 cc/kgm.) to healthy vigorous adrenalectomized dogs induced a rapid decrease in serum Na and chloride conc. an associated fluid shift, blood conc. and circulatory failure similar to the changes characteristic of uncomplicated adrenal insufficiency. Dogs with reserve hormone from intact adrenals showed only slight reductions in serum Na and chloride when subjected to severe, extensive trauma. Animals with intact adrenals were far more resistant to the electrolyte and fluid changes induced by intraperit. glucose and recovered from double the glucose dosage fatal for the adrenalectomized dog. Dogs lacking adrenals or reserve hormone invariably succumbed to these electrolyte and fluid shifts resulting either from trauma or glucose administration unless large doses of cortical hormone were injected, whereupon the normal internal electrolyte and fluid balance was reestablished.