COMPARATIVE-STUDY OF FEMORAL VASODILATATOR EFFECTS OF NAFTIDROFURYL AND NICERGOLINE ON DOG

  • 1 January 1981
    • journal article
    • research article
    • Vol. 12  (3) , 263-275
Abstract
In anesthetized dogs kinetics and efficiency of peripheral vasodilator effects of naftidrofuryl and nicergoline were investigated after intraarterial and i.m. administration. Their possible action on arterial blood pressure was also studied. The study of kinetics of vasodilator effects of naftidrofuryl and nicergoline by the intraarterial route at doses equal to the doses used in clinical practice and the study of the dose-vasodilatation and dose-hypotension regressions for doses of 0.025, 0.050 and 0.100 mg/kg show that naftidrofuryl has a good dilator effect, which is stronger and slightly shorter than that of nicergoline. Nicergoline produces a dose-related decrease in arterial pressure; naftidrofuryl does not alter it. The results obtained by i.m. administration show that naftidrofuryl, at 2, 4 and 8 mg/kg, has a strong and lasting vasodilator effect, proportional to the dose, without alteration of the arterial pressure. Nicergoline, at 0.25, 1 and 4 mg/kg, is very hypotensive. Its vasodilator effect observed by the intraarterial route is not confirmed.