SEMINARS ON LIVER-DISEASE .12. HEPATIC VASCULATURE AND ITS RESPONSE TO HEPATIC INJURY - WORKING HYPOTHESIS

Google Scholar
  • 1 January 1977
    • journal article
    • research article
    • Vol. 50  (5) , 497-506
Abstract
The human hepatic circulation is unique in that high volumes of low pressure blood flow are supplied through a dual venous and arterial circulation. This vascular supply is modulated by the gastrointestinal vascular bed and an intrahepatic microcirculation. This complex vascular system is influenced by pathologic processes within the liver. Alterations in the hepatic circulation reflect hepatic metabolic adaptation and injury. In some circumstances hepatic circulatory alterations are apparently inappropriate, exaggerated or inadequate, and contribute to the initiation or perpetuation of hepatic injury. Studies of the normal and abnormal hepatic circulation that provide insights into hepatic circulatory responses and their role in the initiation and perpetuation of hepatic injury were discussed. A possible relationship of these vascular changes to pathologic processes within the liver is proposed. Ultimately, precise measurement and understanding of hepatic vasculature changes may allow appropriate intervention to offset injury or stimulate maximum effective repair.