Temporal changes in canine right ventricular volume, mass, cell size, and sarcomere length after banding the pulmonary artery

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Abstract
The interrelation of sarcomere length, cell length, ventricular volume, and weight was determined in the right ventricle of normal and pulmonary arterial banded dogs; a temporal model of the acute and chronic compensatory changes of the myocardium is presented. These changes include an early increase in end-diastolic sarcomere length and the occurrence of fibre slippage. Although myocardial hypertrophy diminishes ventricular volume, the ventricle does not completely compensate; therefore, the volume of the ventricle does not return to normal.