Biopolymer Membrane: A Model System for the Study of the Neutrophilic Leukocyte Response to Immune Complexes

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Abstract
A biosynthetic collagen polymer membrane on which specific antibody was linearly deposited provided an in vitro model of anti-glomerular basement membrane antibody nephritis. Exposure of neutrophilic leukocytes to this membrane induced adherence and marked spreading of the cells over the polymer surface. This was associated with release of bioactive substances from the neutrophils and indicated that immunologically induced release of inflammatory factors could occur in the absence of phagocytosis of immune complexes.