EFFECTS OF PARA-METHOXYPHENOL AND DIET ON CARCINOGEN-INDUCED NEOPLASIA OF THE MOUSE FORESTOMACH

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (10) , 4747-4751
Abstract
Previously, p-methoxyphenol fed in the diet was the most potent inhibitor of benzo[a]pyrene-induced neoplasia of the mouse forestomach of 18 phenols investigated. In the present study, the effects of p-methoxyphenol on the direct-acting carcinogen, .beta.-propiolactone (BPL), were determined. p-Methoxyphenol administered at 1 or 4 h prior to BPL or fed in the diet markedly inhibited BPL-induced neoplasia of the mouse forestomch. Of 10 phenols tested by oral intubation, it was the only one that exerted a significant inhibitory activity. Thus far, p-methoxyphenol appears to be an effective inhibitor only when given prior to carcinogen administration. The nature of the diet markedly altered the neoplastic response of the mouse forestomach to BPL but not in benzo[a]pyrene.