Transcatheter Sclerosis of the Gallbladder in Rabbits

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Abstract
Catheter sclerosis of 56 rabbit gallbladders was attempted at laparotomy. The proximal cystic duct was occluded with a hemoclip and transcatheter administration of 6 difference sclerosing agents and a saline control was performed. Eight animals were used for each agent, 3 being sacrificed after 2 wk and the remainder after 6 wk. Hot contrast and sotradecol were comparable with saline in their lack of effect on gallbladder muscosa. Alcohol alone, tetracycline, methylcyanoacrylate and alcohol plus trifluoroacetic acid were successful at 2 wk in denuding the gallbladder epithelium and promoting fibrosis of the gallbladder wall. After 6 wk, evidence of mucosal regeneration was present with all agents, and the epithelium appeared to have grown back from the occluded cystic duct. Late regeneration has not been previously reported and its significance when considering the application of the technique to the human gallbladder in discussed.