New isoflavones, inhibiting catechol-O-methyltransferase, produced by Streptomyces.
- 1 January 1975
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 28 (9) , 619-626
- https://doi.org/10.7164/antibiotics.28.619
Abstract
In the screening of catechol-O-methyltransferase inhibitors in streptomyces culture filtrates, three new isoflavones were isolated. Their structures were shown to be 3',5,7-trihydroxy-4',6-dimethoxyisoflavone (I), 3',5,7-trihydroxy-4',8-dimethoxyisoflavone (II), 3',8-dihydroxy-4',6,7-trimethoxyisoflavone (III). I and II inhibited both catechol-O-methyltransferase and dopa decarboxylase, and showed hypotensive action. III was a specific inhibitor of catechol-O-methyltransferase, and showed no hypotensive action.Keywords
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