Purification of a Plasminogen Activator Inhibitor Indistinguishable from α1-Antitrypsin and an Urokinase Inhibitor in Pregnancy Plasma
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 5 (4) , 218-230
- https://doi.org/10.1159/000214137
Abstract
An inhibitor of urokinase present in increased concentrations in plasma during pregnancy was purified. The inhibitor was identified by its pronounced effect on urokinase-induced fibrinolysis as opposed to the absence of effect on fibrinolysis induced by a tissue plasminogen activator. The inhibitor progressively inactivated urokinase upon incubation and was found to be indistinguishable from α1-antitrypsin.Keywords
This publication has 2 references indexed in Scilit:
- Serum inhibition of plasmin and of plasminogen activation in thrombotic diseasesJournal of Atherosclerosis Research, 1967
- Selective Inhibition in Human Pregnancy Blood of Urokinase Induced EibrinolysisScandinavian Journal of Clinical and Laboratory Investigation, 1963