EFFECT OF STRONTIUM ON THE EPIPHYSEAL CARTILAGE PLATE OF RAT TIBIAE—HISTOLOGICAL AND RADIOGRAPHIC STUDIES

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Abstract
Following dietary administration of strontium carbonate, histological and radiographic changes in the epiphyseal cartilage plate of the rat tibiae were examined. The weight gain of the rat fed a Sr diet was less than that of the control rats. Longitudinal growth of tibiae and endochondral ossification were inhibited by Sr administration. The widths of both proximal and distal cartilage plates increased enormously. Sizes of chondroblasts in columns of proximal cartilage plate in rats fed a Sr diet were smaller than those of the control rats and were not different between upper and lower parts. Sr inhibits bone growth through the inhibitory action on the maturation process of chondroblasts and the succeeding endochondral ossification.

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