IMMUNE-RESPONSE TO IMMUNIZATION VIA ANTERIOR-CHAMBER OF EYE .2. ANALYSIS OF F1 LYMPHOCYTE-INDUCED IMMUNE DEVIATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 120  (3) , 689-693
Abstract
Exposure to alloantigen via the anterior chamber of the [rat] eye elicits a transient suppression of cellular immunity, whereas humoral immunity is preserved.sbd.i.e., F1 LI-ID [lymphocyte-induced immune deviation]. The majority of lymphoid cells inoculated into the anterior chamber are retained within the posterior segment of the eye. The latter serves as a depot of alloantigen, allowing the chronic egress of small numbers of cells into the vascular tree. The persistence of this antigen depot is essential to the development of F1 LI-ID. Since there is a preferential distribution of cells that migrate from the eye to the spleen, the functional integrity of the latter is also necessary to elicit F1 LI-ID. An anatomically intact spleen, i.v. presentation of antigen and persistence of antigen within the eye are all important to the elicitation of this phenomenon.

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