Activation of Liver X Receptors Promotes Neuroprotection and Reduces Brain Inflammation in Experimental Stroke
- 30 September 2008
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 118 (14) , 1450-1459
- https://doi.org/10.1161/circulationaha.108.782300
Abstract
Background— The liver X receptors (LXRs) belong to the nuclear receptor superfamily and act as transcriptional regulators of cholesterol metabolism in several tissues. Recent work also has identifi...Keywords
This publication has 50 references indexed in Scilit:
- Liver X receptor β (LXRβ): A link between β-sitosterol and amyotrophic lateral sclerosis–Parkinson's dementiaProceedings of the National Academy of Sciences, 2008
- Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptorsProceedings of the National Academy of Sciences, 2007
- Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγMolecular Cell, 2007
- Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytesPublished by Elsevier ,2006
- Oxidized low density lipoprotein suppresses lipopolysaccharide-induced inflammatory responses in microglia: Oxidative stress acts through control of inflammationBiochemical and Biophysical Research Communications, 2006
- A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γNature, 2005
- Liver X Receptor-dependent Repression of Matrix Metalloproteinase-9 Expression in MacrophagesJournal of Biological Chemistry, 2003
- ABC1 Gene Expression and ApoA-I-Mediated Cholesterol Efflux Are Regulated by LXRBiochemical and Biophysical Research Communications, 2000
- Activators and target genes of Rel/NF-κB transcription factorsOncogene, 1999
- NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune ResponsesAnnual Review of Immunology, 1998