Urine pH and phencyclidine excretion

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Abstract
Subeffective doses (0.5 mg) of 3H-phencyclidine (PC) were given i.v. to 3 healthy men under 2 regimens designed to alkalinize or acidify their urine (oral sodium bicarbonate or ammonium chloride). The concentrations of PCP and its metabolites in saliva, plasma and urine for 7 h after drug injection were determined by high-performance liquid radiochromatography. A sample of perspiration from 1 subject was analyzed. The effects of physical exercise on the plasma concentration and urinary excretion of PCP were also studied. Multiple linear regression analysis showed the log of renal clearance to be dependent on urine pH (P < 0.0001), the log of urine volume per unit time (P = 0.003) and the individual subject (P = 0.016). Exercise decreased urine pH and increased the renal clearance of PCP. PCP and its metabolites are also excreted in perspiration. Vigorous acidification of urine and diuresis are important in treatment of PCP intoxication.

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