Macrocyclic peptidomimetic inhibitors of β-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex
- 31 December 2005
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (1) , 191-195
- https://doi.org/10.1016/j.bmcl.2005.09.003
Abstract
No abstract availableKeywords
This publication has 24 references indexed in Scilit:
- Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SARBioorganic & Medicinal Chemistry Letters, 2003
- Human β-Secretase (BACE) and BACE InhibitorsJournal of Medicinal Chemistry, 2003
- Vaccines for Alzheimer??s DiseaseCNS Drugs, 2003
- Alzheimer's Disease: Genes, Proteins, and TherapyPhysiological Reviews, 2001
- Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generationNature Neuroscience, 2001
- Implication of APP Secretases in Notch SignalingJournal of Molecular Neuroscience, 2001
- Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with InhibitorScience, 2000
- β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience, 1999
- Translating cell biology into therapeutic advances in Alzheimer's diseaseNature, 1999
- Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reportedPublished by American Medical Association (AMA) ,1989